Center for Joint Medicine & Cartilage Regeneration

Our focus is on preventing joint surgeries by using regenerative methods to preserve joint health.

Focus Areas

Cartilage Regeneration

We promote the natural rebuilding of cartilage.

Meniscus Tears

We treat meniscus tears in a tissue-preserving and regenerative way.

Cruciate Ligament Injuries

We strengthen cruciate ligaments through regenerative cell therapy.

Muscle, Ligament, and Tendon Injuries

We specifically stimulate the healing of tendons, ligaments, and muscles.

Science & Medicine

Mechanism of Action

Cell-Based Regeneration for Sustainable Joint Health

We focus on regenerating injured or worn tissue structures rather than removing or replacing them.

To achieve this, we use carefully selected and individually tailored procedures that are supported by numerous studies and whose effects are well researched. The cell-based and cell-free regenerative methods we apply promote tissue regeneration and reduce inflammatory processes in the joint and the injured structures. This allows us to break the vicious cycle of wear–inflammation–further wear.

Our Focus Areas

Preserve and regenerate, not remove or replace
Individual, evidence-based therapy
Use of cell-based and cell-free methods
Anti-inflammatory action and tissue healing
Breaking the cycle of wear and inflammation

Methods

Innovative Regenerative Methods for Cartilage & Joints

Avancell Joint Repair – These are specially designed treatment plans tailored precisely to your needs. Our goal: to preserve your joint and improve your quality of life. We aim to avoid surgery whenever possible and fully harness the regenerative potential of the body. Depending on the type of tissue or cartilage damage, we combine state-of-the-art therapies to achieve the greatest healing effect. Avancell is the first institute worldwide to implement regenerative medicine for cartilage within its own standardized treatment protocol.

How does it work?

First, we analyze the extent and type of tissue or cartilage damage. For this, we require MRI images not older than three months. We are happy to arrange a referral for you. Based on this analysis and our Avancell Joint Repair treatment standard, we then create a fully individualized treatment plan for you.

The severity of tissue and cartilage damage is also decisive:

Avancell Stage I

Mild cartilage damage (Osteoarthritis Grade I–II) with mild inflammatory reaction or slight joint effusion (Pain VAS 0–3).

Avancell Stage II

Moderate cartilage damage (Osteoarthritis Grade III) with moderate inflammatory reaction or moderate joint effusion (Pain VAS 4–6).

Avancell Stage III

Severe cartilage damage (Osteoarthritis Grade IV) with strong inflammatory reaction or severe joint effusion (Pain VAS >6).

Regeneration with the Body’s Own Cells

Stem cells have the ability to develop into different types of tissue, including cartilage cells. We obtain stem cells from adipose tissue, bone marrow, or peripheral blood. After processing, they are precisely injected into the affected joint.

In addition to stem cells, anti-inflammatory cytokines and growth factors are also released, further supporting the body’s natural healing process.

How Stem Cells Work in Osteoarthritis

Stem cells offer an innovative therapeutic approach for osteoarthritis because they combine anti-inflammatory and regenerative properties. Their primary goal is to positively influence the diseased joint environment and activate the body’s natural healing and regeneration processes.

A key mechanism is the targeted modulation of the chronic inflammatory response within the arthritic joint. Mesenchymal stem cells release numerous bioactive signaling molecules that regulate the immune system and can significantly reduce the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6).

At the same time, stem cells promote the release of anti-inflammatory mediators and create a biological environment that supports regeneration and may help slow the progression of cartilage degeneration.

Furthermore, stem cells stimulate the activity of the body’s own cartilage cells and support the formation of new cartilage matrix. By releasing growth factors, they promote repair and regeneration within the joint, helping improve cartilage quality while preserving joint structure. They also support the regeneration of surrounding joint tissues, including the synovial membrane and subchondral bone.

The combined effect of reducing inflammation and promoting tissue regeneration can lead to lasting improvements in joint function. Many patients report significant pain relief, improved mobility, and greater resilience in everyday life. The goal of stem cell therapy is to slow the progression of osteoarthritis, enhance the joint’s regenerative capacity, and contribute to a better quality of life over the long term.

Stem Cells for Osteoarthritis, ACL and Meniscus Injuries

Stem cells are opening new possibilities in modern orthopedics for the biological treatment of joint disorders and sports injuries. Mesenchymal stem cells, in particular, possess anti-inflammatory, immunomodulatory, and regenerative properties that actively support the body’s natural healing processes.

In osteoarthritis, stem cells help restore a healthier joint environment. They regulate the chronic inflammatory response and reduce the release of pro-inflammatory signaling molecules such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). At the same time, they promote the release of anti-inflammatory mediators, creating optimal conditions for tissue repair and regeneration. Stem cells also stimulate the body’s own cartilage cells and support the formation of new cartilage matrix. This can slow cartilage degeneration, enhance cartilage regeneration, relieve pain, and improve long-term joint function.

Stem cells can also make a valuable contribution to the healing of ACL injuries. By releasing growth factors and regenerative signaling molecules, they promote the formation of new collagen fibers, support the healing of injured ligament tissue, and improve the quality of tissue repair. Following ACL reconstruction, they may also enhance biological graft integration into the bone and support the regeneration of surrounding tissues.

In meniscus injuries, stem cells promote the regeneration of meniscal tissue by stimulating cell growth and the formation of extracellular matrix. At the same time, they reduce inflammation within the joint and create a regenerative environment that supports meniscus healing. This can improve meniscal stability and function while helping reduce the risk of premature joint degeneration.

Through their combined anti-inflammatory, immunoregulatory, and regenerative effects, stem cells support the healing of cartilage, ligament, and meniscal injuries. The goal of treatment is to promote the regeneration of damaged tissues, reduce pain, improve joint function, and restore mobility and long-term resilience as completely as possible.

Cell Signaling Molecules – The Key to Communication & Healing

Exosomes are tiny vesicles that cells use to communicate. They transport healing signals between cells and play a crucial role in regulating regeneration and inflammation.

We use stem cell–derived or platelet-derived exosomes to treat cartilage damage and osteoarthritis—an approach supported by scientific evidence and proven in clinical practice.

Exosomes for Osteoarthritis

Exosomes are microscopic biological vesicles released by cells that contain a wide range of signaling molecules, including proteins, lipids, growth factors, and regulatory RNA molecules. They enable communication between cells and play a central role in controlling inflammation and tissue regeneration. Exosomes derived from mesenchymal stem cells are considered one of the key mechanisms through which stem cells exert their therapeutic effects.

In osteoarthritis, exosomes help regulate the inflammatory environment within the joint. They modulate immune cell activity and reduce the release of pro-inflammatory signaling molecules such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). At the same time, they promote the production of anti-inflammatory mediators, helping to reduce chronic joint inflammation.

Furthermore, exosomes stimulate the activity of cartilage cells (chondrocytes), promote the production of collagen type II and proteoglycans, and support cartilage regeneration. At the same time, they inhibit enzymes responsible for cartilage breakdown, helping to slow the progression of joint degeneration.

In addition to their effects on articular cartilage, exosomes also promote the regeneration of the synovial membrane, subchondral bone, and other surrounding joint tissues. This helps restore a healthy biological joint environment and supports the body’s natural repair mechanisms.

The goal of exosome therapy is to reduce inflammation, relieve pain, improve joint function, and promote the regeneration of joint tissues. Because exosomes contain the biological signaling molecules of stem cells, they can deliver many of the regenerative and anti-inflammatory benefits of stem cell therapy without requiring the transfer of living cells.

Research on exosomes is advancing rapidly. Preclinical studies and early clinical investigations have shown promising results in pain relief, improved joint function, and support of cartilage regeneration. However, larger clinical studies are still needed to confirm their effectiveness, establish optimal dosing, and evaluate long-term outcomes.

Healing from Your Own Blood

Exosomes are tiny vesicles that cells use to communicate. They transport healing signals between cells and play a crucial role in regulating regeneration and inflammation.

We use stem cell–derived or platelet-derived exosomes to treat cartilage damage and osteoarthritis—an approach supported by scientific evidence and proven in clinical practice.

Platelet-Rich Plasma (PRP)

Platelet-rich plasma (PRP) is an innovative biological treatment that harnesses the body’s natural healing and regenerative potential. A small sample of the patient’s own blood is collected and processed using a specialized technique to create plasma with a significantly higher concentration of platelets (thrombocytes), which are rich in growth factors and biologically active signaling molecules.

After injection into the affected joint or injured tissue, the platelets release numerous growth factors, including Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor-beta (TGF-β), Vascular Endothelial Growth Factor (VEGF), and Insulin-like Growth Factor-1 (IGF-1).

In osteoarthritis, PRP helps reduce the chronic inflammatory response within the joint. It can lower the levels of pro-inflammatory signaling molecules such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) while promoting the release of anti-inflammatory mediators. This improves the biological joint environment, helps relieve pain, and can lead to lasting improvements in joint function. PRP also stimulates the activity of cartilage cells and supports the formation of new cartilage matrix, promoting cartilage regeneration.

PRP also supports the natural healing of tendon injuries, ligament injuries, meniscus injuries, and postoperative tissue repair. The growth factors it contains stimulate the formation of new collagen fibers, accelerate tissue regeneration, and improve the quality of healing.

Because PRP is produced exclusively from the patient’s own blood, it is highly biocompatible and carries only a minimal risk of allergic reactions or intolerance. It is often combined with arthroscopic procedures, stem cell therapy, exosome therapy, or cartilage regeneration techniques to further enhance the body’s natural healing response.

The goal of PRP therapy is to reduce pain and inflammation, promote the regeneration of cartilage, tendons, ligaments, and muscles, improve joint function, and support a faster return to everyday activities, work, and sports.

Structures That Guide Healing Cells to the Right Place

Scaffolds are specialized carrier materials—either solid or injectable—that are placed directly into the damaged cartilage area. Their purpose is to attract and retain stem cells exactly where they are needed, improving local tissue regeneration within the defect.

Scaffolds and Biological Matrices for Cartilage Repair

Scaffolds and biological matrices are among the most advanced techniques in regenerative cartilage surgery. They provide a three-dimensional framework that creates the ideal environment for the body’s own cells to generate new cartilage tissue. Their goal is to biologically repair cartilage defects, restore joint function, and prevent or slow the progression of osteoarthritis.

After careful preparation of the cartilage defect, the scaffold or matrix is implanted into the affected area. The biomaterial serves as a biological framework into which the body’s own stem cells or transplanted cartilage cells can migrate. Within this structure, the cells attach, multiply, and produce new cartilage matrix containing collagen and proteoglycans. At the same time, the scaffold protects the regenerating cells and supports organized tissue healing.

Scaffolds are often combined with cartilage regeneration techniques such as microfracture, autologous chondrocyte implantation (ACI), or biological therapies including PRP, stem cells, and exosomes. These combinations can further enhance the regenerative process and improve the quality of newly formed cartilage tissue.

Depending on the technique, biological matrices are made from collagen, hyaluronic acid, or other biocompatible materials. Over time, they are gradually broken down by the body and replaced with newly formed native tissue, creating a stable foundation for long-term cartilage regeneration.

Modern scaffold and matrix techniques enable the biological reconstruction of cartilage defects and offer excellent treatment options, particularly for localized cartilage damage. The goal is to reduce pain, restore joint function, promote the body’s natural cartilage regeneration, and help prevent or slow the long-term progression of osteoarthritis.

Minimally Invasive Procedures – Only When Necessary

In selected cases, arthroscopy or nanoscopy may be beneficial—for example, to clean the joint or perform minor procedures. Using an ultra-fine camera, sometimes as thin as a needle, treatment is carried out with maximum precision and minimal tissue disruption. The procedure usually takes only a few minutes and is performed on an outpatient basis.

Knee Nanoscopy

Knee nanoscopy is the latest generation of minimally invasive joint imaging. It uses an ultra-thin, high-resolution nano-arthroscope with a diameter of only about 2 mm. In many cases, both diagnosis and treatment can be performed on an outpatient basis under local anesthesia.

Nanoscopy allows direct and highly precise evaluation of all key structures within the knee joint, including the meniscus, cruciate ligaments, articular cartilage, and synovial membrane. Compared with magnetic resonance imaging (MRI), it provides immediate visualization of the joint and enables an accurate diagnosis. At the same time, many minor injuries or abnormalities can be treated immediately.

Nanoscopy for Meniscus Injuries

Nanoscopy is ideally suited for the diagnosis and treatment of selected meniscal injuries. Unstable meniscal tissue can be smoothed, small tears assessed and—where appropriate—treated using minimally invasive techniques. By preserving as much healthy meniscal tissue as possible, the knee’s natural shock-absorbing function is maintained.

Nanoscopy for Cartilage Injuries

Cartilage damage can also be detected early and treated precisely using nanoscopy. Smaller cartilage defects can be carefully smoothed or prepared for cartilage regeneration procedures. This helps support cartilage repair and may slow the progression of joint degeneration.

Nanoscopy for ACL Injuries

Nanoscopy enables precise evaluation of the cruciate ligaments and helps reliably detect partial tears and associated injuries. It supports the decision between conservative treatment and surgical reconstruction. It is also valuable for monitoring the healing process following ACL reconstruction.

Benefits of Nanoscopy

Thanks to its ultra-small instruments, nanoscopy is especially gentle on surrounding tissues. Smaller incisions result in less pain, reduced swelling, and faster recovery. Many patients are able to bear weight shortly after the procedure and return to everyday activities more quickly.

Nanoscopy combines outstanding diagnostic accuracy with maximum tissue preservation and represents a major advancement in modern knee surgery. It enables earlier diagnosis, highly individualized treatment, and helps preserve long-term joint function.Nanoscopy combines outstanding diagnostic accuracy with maximum tissue preservation and represents a major advancement in modern knee surgery. It enables earlier diagnosis, highly individualized treatment, and helps preserve long-term joint function.

Osteoarthritis is more than simple wear and tear—it is a chronic inflammatory disease.
The Auricore® method uses tiny gold implants (1 × 2 mm) that are placed directly into the joint lining. These release gold ions that attract and selectively deactivate inflammation-driving immune cells.

Benefits at a Glance:

Modulates the immune system instead of merely suppressing it
Reduces inflammation and pain
Protects cartilage from further degradation
No long-term medication required
Improved mobility and quality of life

This treatment has already been used successfully in patients with chronic osteoarthritis pain—often with impressive results and without the need for surgery.

Auricore – Gold Implants to Support Healthy Joint Function

Auricore consists of tiny cylinders made of 99.9% pure gold, which are implanted around the joint capsule during a minimally invasive procedure. The implants remain permanently in the tissue, where they are designed to exert their effects directly at the site of inflammation.

According to the proposed mechanism of action, small amounts of gold ions are released around the implants. These ions are thought to influence the activity of various immune cells, including mast cells and macrophages, helping to modulate the immune response and reduce excessive inflammation.

A central role is played by inflammatory cytokines—the signaling molecules of the immune system that regulate inflammatory processes. Among the most important are interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α). IL-6 promotes inflammatory responses and can contribute to pain and cartilage degradation. TNF-α is one of the key inflammatory mediators and further stimulates immune cell activation as well as the release of additional pro-inflammatory signaling molecules.

According to the proposed concept of gold implantation, the release of pro-inflammatory cytokines—including IL-6, TNF-α, and other inflammatory signaling molecules—is intended to be reduced locally within the affected joint. This helps calm the inflammatory environment and supports the body’s natural regulation of the immune system.

As inflammation decreases, pain may be relieved, joint mobility can improve, and the overall impact of symptoms on daily life may be reduced. Many patients report noticeable improvements in everyday activities and enhanced quality of life. The goal of treatment is to support healthy joint function over the long term and help patients regain confidence and enjoyment in movement.

Denervation for Grade IV Osteoarthritis

Grade IV osteoarthritis is characterized by advanced joint degeneration with extensive loss of articular cartilage. The exposed bone surfaces may rub against each other, causing significant pain and severely limiting mobility. Not every patient is a suitable candidate for joint replacement or wishes to undergo end-stage surgery. In carefully selected cases, denervation can provide an effective option for pain relief.

Denervation is a minimally invasive procedure that selectively targets the pain-transmitting nerve branches surrounding the affected joint. The goal is to interrupt pain signals before they reach the brain while preserving the joint’s stability, mobility, and function.

Although denervation does not treat the underlying osteoarthritis, it is specifically aimed at relieving chronic joint pain. Many patients experience significant pain reduction, improved mobility, and greater ability to perform everyday activities. This can often reduce the need for pain medication and substantially improve quality of life.

This procedure is particularly suitable for patients with advanced osteoarthritis who have not achieved sufficient relief with conservative treatments, wish to delay joint replacement surgery, or have an increased surgical risk due to underlying medical conditions.

Denervation is typically performed as an outpatient, minimally invasive procedure. By selectively disabling the pain-transmitting nerves, symptoms can often be relieved for months or even years. If pain returns, the procedure can be repeated when clinically appropriate.

Denervation is therefore a modern, joint-preserving treatment option for chronic osteoarthritis pain. It can significantly improve quality of life, help maintain mobility, and enable many patients to return to a more active and less painful everyday life.

Minimally Invasive Procedures Only When Necessary

PD Dr. Weninger has taken cruciate ligament reconstruction to the next level with “Advanced ACL Repair”: an especially gentle operation with no drains, no tourniquet, short surgery time, and individualized approach. In addition, state-of-the-art techniques are used, including stem cells, reinforcement of the torn ligament, or highly effective scaffolds. Whether refixation or replacement of the cruciate ligament, patients of knee specialist Dr. Weninger benefit from this high-tech ACL reconstruction.

Dr. Weninger and his experienced team have perfected cruciate ligament reconstruction, so that numerous professional and recreational athletes rely on “Advanced ACL Repair” and the “Weninger ACL”. Ensuring a safe and reliable comeback for his patients is Dr. Weninger’s top priority.

Stem Cells for Cruciate Ligament Tears

PD Dr. Weninger uses stem cells to treat cruciate ligament injuries. These are introduced into the knee either during a minor surgical procedure or non-surgically, promoting healing of the torn ligament. For his patients, Dr. Weninger exclusively uses a special collagen scaffold and a specific growth factor. This encourages the stem cells to differentiate into fibroblasts and form collagen fibers, allowing the injured ligament to heal.

PD Dr. Weninger was the first orthopedic surgeon worldwide to publish and apply this method, known as #bioaclrepair. Approximately 300 patients are treated this way each year. Surgery is often avoided, and the anterior cruciate ligament is preserved. Suitability depends on the type of tear and blood supply. Using a specialized AI program (#aicl), Dr. Weninger can plan stem cell therapy for cruciate ligament tears.

Treating Meniscus Tears with Stem Cells and Fibrin Glue

PD Dr. Weninger uses a particularly gentle method for meniscus tears. Instead of simply removing the meniscus during surgery, it is carefully stabilized with a special tissue adhesive, preserving all meniscus tissue. In addition, Dr. Weninger uses stem cells to treat the meniscus tear.

His patients also receive a special scaffold to ensure that the stem cells reliably differentiate into fibroblasts, allowing the meniscus to heal. This method was published by Dr. Weninger and is one of his signature treatments, developed exclusively for his patients.

Nanoscopy with Stem Cells

As a knee specialist, PD Dr. Weninger uses an especially gentle surgical technique: nanoscopy. A nano-camera, no thicker than a needle, is used for the procedure. These interventions are combined with stem cells and are applied for the following conditions:

The procedure is performed under local anesthesia and is particularly gentle and effective.

Gold Implantation for Osteoarthritis

For advanced Grade IV osteoarthritis with severe pain, PD Dr. Weninger performs gold implantation. Tiny gold cylinders are implanted into the joint capsule under local anesthesia. This immediately down-regulates the inflammation triggered by osteoarthritis in the joint.

Patients are usually pain-free right away, and a prosthesis through major surgery can often be avoided. The procedure is particularly gentle and can be performed under local anesthesia.

Denervation for Grade IV Osteoarthritis

As a knee specialist, PD Dr. Weninger is an expert in pain elimination for Grade IV osteoarthritis. He uses needle-like electrodes to deactivate the pain fibers, providing patients with immediate relief. The procedure is particularly gentle and can be performed under local anesthesia.

Avancell Methods

Avancell Joint Repair – These are specially designed treatment plans tailored precisely to your needs. Our goal: to preserve your joint and improve your quality of life. We aim to avoid surgery whenever possible and fully harness the regenerative potential of the body. Depending on the type of tissue or cartilage damage, we combine state-of-the-art therapies to achieve the greatest healing effect. Avancell is the first institute worldwide to implement regenerative medicine for cartilage within its own standardized treatment protocol.

How does it work?

First, we analyze the extent and type of tissue or cartilage damage. For this, we require MRI images not older than three months. We are happy to arrange a referral for you. Based on this analysis and our Avancell Joint Repair treatment standard, we then create a fully individualized treatment plan for you.

The severity of tissue and cartilage damage is also decisive:

Avancell Stage I

Mild cartilage damage (Osteoarthritis Grade I–II) with mild inflammatory reaction or slight joint effusion (Pain VAS 0–3).

Avancell Stage II

Moderate cartilage damage (Osteoarthritis Grade III) with moderate inflammatory reaction or moderate joint effusion (Pain VAS 4–6).

Avancell Stage III

Severe cartilage damage (Osteoarthritis Grade IV) with strong inflammatory reaction or severe joint effusion (Pain VAS >6).

Stem Cell Therapy

Regeneration with the Body’s Own Cells

Stem cells have the ability to develop into different types of tissue, including cartilage cells. We obtain stem cells from adipose tissue, bone marrow, or peripheral blood. After processing, they are precisely injected into the affected joint.

In addition to stem cells, anti-inflammatory cytokines and growth factors are also released, further supporting the body’s natural healing process.

How Stem Cells Work in Osteoarthritis

Stem cells offer an innovative therapeutic approach for osteoarthritis because they combine anti-inflammatory and regenerative properties. Their primary goal is to positively influence the diseased joint environment and activate the body’s natural healing and regeneration processes.

A key mechanism is the targeted modulation of the chronic inflammatory response within the arthritic joint. Mesenchymal stem cells release numerous bioactive signaling molecules that regulate the immune system and can significantly reduce the production of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6).

At the same time, stem cells promote the release of anti-inflammatory mediators and create a biological environment that supports regeneration and may help slow the progression of cartilage degeneration.

Furthermore, stem cells stimulate the activity of the body’s own cartilage cells and support the formation of new cartilage matrix. By releasing growth factors, they promote repair and regeneration within the joint, helping improve cartilage quality while preserving joint structure. They also support the regeneration of surrounding joint tissues, including the synovial membrane and subchondral bone.

The combined effect of reducing inflammation and promoting tissue regeneration can lead to lasting improvements in joint function. Many patients report significant pain relief, improved mobility, and greater resilience in everyday life. The goal of stem cell therapy is to slow the progression of osteoarthritis, enhance the joint’s regenerative capacity, and contribute to a better quality of life over the long term.

Stem Cells for Osteoarthritis, ACL and Meniscus Injuries

Stem cells are opening new possibilities in modern orthopedics for the biological treatment of joint disorders and sports injuries. Mesenchymal stem cells, in particular, possess anti-inflammatory, immunomodulatory, and regenerative properties that actively support the body’s natural healing processes.

In osteoarthritis, stem cells help restore a healthier joint environment. They regulate the chronic inflammatory response and reduce the release of pro-inflammatory signaling molecules such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). At the same time, they promote the release of anti-inflammatory mediators, creating optimal conditions for tissue repair and regeneration. Stem cells also stimulate the body’s own cartilage cells and support the formation of new cartilage matrix. This can slow cartilage degeneration, enhance cartilage regeneration, relieve pain, and improve long-term joint function.

Stem cells can also make a valuable contribution to the healing of ACL injuries. By releasing growth factors and regenerative signaling molecules, they promote the formation of new collagen fibers, support the healing of injured ligament tissue, and improve the quality of tissue repair. Following ACL reconstruction, they may also enhance biological graft integration into the bone and support the regeneration of surrounding tissues.

In meniscus injuries, stem cells promote the regeneration of meniscal tissue by stimulating cell growth and the formation of extracellular matrix. At the same time, they reduce inflammation within the joint and create a regenerative environment that supports meniscus healing. This can improve meniscal stability and function while helping reduce the risk of premature joint degeneration.

Through their combined anti-inflammatory, immunoregulatory, and regenerative effects, stem cells support the healing of cartilage, ligament, and meniscal injuries. The goal of treatment is to promote the regeneration of damaged tissues, reduce pain, improve joint function, and restore mobility and long-term resilience as completely as possible.

Exosomes

Cell Signaling Molecules – The Key to Communication & Healing

Exosomes are tiny vesicles that cells use to communicate. They transport healing signals between cells and play a crucial role in regulating regeneration and inflammation.

We use stem cell–derived or platelet-derived exosomes to treat cartilage damage and osteoarthritis—an approach supported by scientific evidence and proven in clinical practice.

Exosomes for Osteoarthritis

Exosomes are microscopic biological vesicles released by cells that contain a wide range of signaling molecules, including proteins, lipids, growth factors, and regulatory RNA molecules. They enable communication between cells and play a central role in controlling inflammation and tissue regeneration. Exosomes derived from mesenchymal stem cells are considered one of the key mechanisms through which stem cells exert their therapeutic effects.

In osteoarthritis, exosomes help regulate the inflammatory environment within the joint. They modulate immune cell activity and reduce the release of pro-inflammatory signaling molecules such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). At the same time, they promote the production of anti-inflammatory mediators, helping to reduce chronic joint inflammation.

Furthermore, exosomes stimulate the activity of cartilage cells (chondrocytes), promote the production of collagen type II and proteoglycans, and support cartilage regeneration. At the same time, they inhibit enzymes responsible for cartilage breakdown, helping to slow the progression of joint degeneration.

In addition to their effects on articular cartilage, exosomes also promote the regeneration of the synovial membrane, subchondral bone, and other surrounding joint tissues. This helps restore a healthy biological joint environment and supports the body’s natural repair mechanisms.

The goal of exosome therapy is to reduce inflammation, relieve pain, improve joint function, and promote the regeneration of joint tissues. Because exosomes contain the biological signaling molecules of stem cells, they can deliver many of the regenerative and anti-inflammatory benefits of stem cell therapy without requiring the transfer of living cells.

Research on exosomes is advancing rapidly. Preclinical studies and early clinical investigations have shown promising results in pain relief, improved joint function, and support of cartilage regeneration. However, larger clinical studies are still needed to confirm their effectiveness, establish optimal dosing, and evaluate long-term outcomes.

Platelet-Rich Plasma (PRP)

Healing from Your Own Blood

This treatment uses the patient’s own blood to produce platelet-rich plasma (PRP). The growth factors it contains support the healing of cartilage tissue and can significantly reduce pain.

When indicated, we also use Autologous Conditioned Serum (ACS)—an advanced biological therapy enriched with additional anti-inflammatory signaling molecules.

Platelet-Rich Plasma (PRP)

Platelet-rich plasma (PRP) is an innovative biological treatment that harnesses the body’s natural healing and regenerative potential. A small sample of the patient’s own blood is collected and processed using a specialized technique to create plasma with a significantly higher concentration of platelets (thrombocytes), which are rich in growth factors and biologically active signaling molecules.

After injection into the affected joint or injured tissue, the platelets release numerous growth factors, including Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor-beta (TGF-β), Vascular Endothelial Growth Factor (VEGF), and Insulin-like Growth Factor-1 (IGF-1).

In osteoarthritis, PRP helps reduce the chronic inflammatory response within the joint. It can lower the levels of pro-inflammatory signaling molecules such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) while promoting the release of anti-inflammatory mediators. This improves the biological joint environment, helps relieve pain, and can lead to lasting improvements in joint function. PRP also stimulates the activity of cartilage cells and supports the formation of new cartilage matrix, promoting cartilage regeneration.

PRP also supports the natural healing of tendon injuries, ligament injuries, meniscus injuries, and postoperative tissue repair. The growth factors it contains stimulate the formation of new collagen fibers, accelerate tissue regeneration, and improve the quality of healing.

Because PRP is produced exclusively from the patient’s own blood, it is highly biocompatible and carries only a minimal risk of allergic reactions or intolerance. It is often combined with arthroscopic procedures, stem cell therapy, exosome therapy, or cartilage regeneration techniques to further enhance the body’s natural healing response.

The goal of PRP therapy is to reduce pain and inflammation, promote the regeneration of cartilage, tendons, ligaments, and muscles, improve joint function, and support a faster return to everyday activities, work, and sports.

Scaffolds

Structures That Guide Healing Cells to the Right Place

Scaffolds are specialized carrier materials—either solid or injectable—that are placed directly into the damaged cartilage area. Their purpose is to attract and retain stem cells exactly where they are needed, improving local tissue regeneration within the defect.

Scaffolds and Biological Matrices for Cartilage Repair

Scaffolds and biological matrices are among the most advanced techniques in regenerative cartilage surgery. They provide a three-dimensional framework that creates the ideal environment for the body’s own cells to generate new cartilage tissue. Their goal is to biologically repair cartilage defects, restore joint function, and prevent or slow the progression of osteoarthritis.

After careful preparation of the cartilage defect, the scaffold or matrix is implanted into the affected area. The biomaterial serves as a biological framework into which the body’s own stem cells or transplanted cartilage cells can migrate. Within this structure, the cells attach, multiply, and produce new cartilage matrix containing collagen and proteoglycans. At the same time, the scaffold protects the regenerating cells and supports organized tissue healing.

Scaffolds are often combined with cartilage regeneration techniques such as microfracture, autologous chondrocyte implantation (ACI), or biological therapies including PRP, stem cells, and exosomes. These combinations can further enhance the regenerative process and improve the quality of newly formed cartilage tissue.

Depending on the technique, biological matrices are made from collagen, hyaluronic acid, or other biocompatible materials. Over time, they are gradually broken down by the body and replaced with newly formed native tissue, creating a stable foundation for long-term cartilage regeneration.

Modern scaffold and matrix techniques enable the biological reconstruction of cartilage defects and offer excellent treatment options, particularly for localized cartilage damage. The goal is to reduce pain, restore joint function, promote the body’s natural cartilage regeneration, and help prevent or slow the long-term progression of osteoarthritis.

Arthroscopy / Nanoscopy

Minimally Invasive Procedures – Only When Necessary

In selected cases, arthroscopy or nanoscopy may be beneficial—for example, to clean the joint or perform minor procedures. Using an ultra-fine camera, sometimes as thin as a needle, treatment is carried out with maximum precision and minimal tissue disruption. The procedure usually takes only a few minutes and is performed on an outpatient basis.

Knee Nanoscopy

Knee nanoscopy is the latest generation of minimally invasive joint imaging. It uses an ultra-thin, high-resolution nano-arthroscope with a diameter of only about 2 mm. In many cases, both diagnosis and treatment can be performed on an outpatient basis under local anesthesia.

Nanoscopy allows direct and highly precise evaluation of all key structures within the knee joint, including the meniscus, cruciate ligaments, articular cartilage, and synovial membrane. Compared with magnetic resonance imaging (MRI), it provides immediate visualization of the joint and enables an accurate diagnosis. At the same time, many minor injuries or abnormalities can be treated immediately.

Nanoscopy for Meniscus Injuries

Nanoscopy is ideally suited for the diagnosis and treatment of selected meniscal injuries. Unstable meniscal tissue can be smoothed, small tears assessed and—where appropriate—treated using minimally invasive techniques. By preserving as much healthy meniscal tissue as possible, the knee’s natural shock-absorbing function is maintained.

Nanoscopy for Cartilage Injuries

Cartilage damage can also be detected early and treated precisely using nanoscopy. Smaller cartilage defects can be carefully smoothed or prepared for cartilage regeneration procedures. This helps support cartilage repair and may slow the progression of joint degeneration.

Nanoscopy for ACL Injuries

Nanoscopy enables precise evaluation of the cruciate ligaments and helps reliably detect partial tears and associated injuries. It supports the decision between conservative treatment and surgical reconstruction. It is also valuable for monitoring the healing process following ACL reconstruction.

Benefits of Nanoscopy

Thanks to its ultra-small instruments, nanoscopy is especially gentle on surrounding tissues. Smaller incisions result in less pain, reduced swelling, and faster recovery. Many patients are able to bear weight shortly after the procedure and return to everyday activities more quickly.

Nanoscopy combines outstanding diagnostic accuracy with maximum tissue preservation and represents a major advancement in modern knee surgery. It enables earlier diagnosis, highly individualized treatment, and helps preserve long-term joint function.

Auricore

Osteoarthritis is more than simple wear and tear—it is a chronic inflammatory disease.
The Auricore® method uses tiny gold implants (1 × 2 mm) that are placed directly into the joint lining. These release gold ions that attract and selectively deactivate inflammation-driving immune cells.

Benefits at a Glance:

Modulates the immune system instead of merely suppressing it
Reduces inflammation and pain
Protects cartilage from further degradation
No long-term medication required
Improved mobility and quality of life

This treatment has already been used successfully in patients with chronic osteoarthritis pain—often with impressive results and without the need for surgery.

Auricore – Gold Implants to Support Healthy Joint Function

Auricore consists of tiny cylinders made of 99.9% pure gold, which are implanted around the joint capsule during a minimally invasive procedure. The implants remain permanently in the tissue, where they are designed to exert their effects directly at the site of inflammation.

According to the proposed mechanism of action, small amounts of gold ions are released around the implants. These ions are thought to influence the activity of various immune cells, including mast cells and macrophages, helping to modulate the immune response and reduce excessive inflammation.

A central role is played by inflammatory cytokines—the signaling molecules of the immune system that regulate inflammatory processes. Among the most important are interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α). IL-6 promotes inflammatory responses and can contribute to pain and cartilage degradation. TNF-α is one of the key inflammatory mediators and further stimulates immune cell activation as well as the release of additional pro-inflammatory signaling molecules.

According to the proposed concept of gold implantation, the release of pro-inflammatory cytokines—including IL-6, TNF-α, and other inflammatory signaling molecules—is intended to be reduced locally within the affected joint. This helps calm the inflammatory environment and supports the body’s natural regulation of the immune system.

As inflammation decreases, pain may be relieved, joint mobility can improve, and the overall impact of symptoms on daily life may be reduced. Many patients report noticeable improvements in everyday activities and enhanced quality of life. The goal of treatment is to support healthy joint function over the long term and help patients regain confidence and enjoyment in movement.As inflammation decreases, pain may be relieved, joint mobility can improve, and the overall impact of symptoms on daily life may be reduced. Many patients report noticeable improvements in everyday activities and enhanced quality of life. The goal of treatment is to support healthy joint function over the long term and help patients regain confidence and enjoyment in movement.

Denervation for Grade IV Osteoarthritis

Grade IV osteoarthritis is characterized by advanced joint degeneration with extensive loss of articular cartilage. The exposed bone surfaces may rub against each other, causing significant pain and severely limiting mobility. Not every patient is a suitable candidate for joint replacement or wishes to undergo end-stage surgery. In carefully selected cases, denervation can provide an effective option for pain relief.

Denervation is a minimally invasive procedure that selectively targets the pain-transmitting nerve branches surrounding the affected joint. The goal is to interrupt pain signals before they reach the brain while preserving the joint’s stability, mobility, and function.

Although denervation does not treat the underlying osteoarthritis, it is specifically aimed at relieving chronic joint pain. Many patients experience significant pain reduction, improved mobility, and greater ability to perform everyday activities. This can often reduce the need for pain medication and substantially improve quality of life.

This procedure is particularly suitable for patients with advanced osteoarthritis who have not achieved sufficient relief with conservative treatments, wish to delay joint replacement surgery, or have an increased surgical risk due to underlying medical conditions.

Denervation is typically performed as an outpatient, minimally invasive procedure. By selectively disabling the pain-transmitting nerves, symptoms can often be relieved for months or even years. If pain returns, the procedure can be repeated when clinically appropriate.

Denervation is therefore a modern, joint-preserving treatment option for chronic osteoarthritis pain. It can significantly improve quality of life, help maintain mobility, and enable many patients to return to a more active and less painful everyday life.

Dr. Weninger Signature Treatments

Minimally Invasive Procedures Only When Necessary

PD Dr. Weninger has taken cruciate ligament reconstruction to the next level with “Advanced ACL Repair”: an especially gentle operation with no drains, no tourniquet, short surgery time, and individualized approach. In addition, state-of-the-art techniques are used, including stem cells, reinforcement of the torn ligament, or highly effective scaffolds. Whether refixation or replacement of the cruciate ligament, patients of knee specialist Dr. Weninger benefit from this high-tech ACL reconstruction.

Dr. Weninger and his experienced team have perfected cruciate ligament reconstruction, so that numerous professional and recreational athletes rely on “Advanced ACL Repair” and the “Weninger ACL”. Ensuring a safe and reliable comeback for his patients is Dr. Weninger’s top priority.

Stem Cells for Cruciate Ligament Tears

PD Dr. Weninger uses stem cells to treat cruciate ligament injuries. These are introduced into the knee either during a minor surgical procedure or non-surgically, promoting healing of the torn ligament. For his patients, Dr. Weninger exclusively uses a special collagen scaffold and a specific growth factor. This encourages the stem cells to differentiate into fibroblasts and form collagen fibers, allowing the injured ligament to heal.

PD Dr. Weninger was the first orthopedic surgeon worldwide to publish and apply this method, known as #bioaclrepair. Approximately 300 patients are treated this way each year. Surgery is often avoided, and the anterior cruciate ligament is preserved. Suitability depends on the type of tear and blood supply. Using a specialized AI program (#aicl), Dr. Weninger can plan stem cell therapy for cruciate ligament tears.

Treating Meniscus Tears with Stem Cells and Fibrin Glue

PD Dr. Weninger uses a particularly gentle method for meniscus tears. Instead of simply removing the meniscus during surgery, it is carefully stabilized with a special tissue adhesive, preserving all meniscus tissue. In addition, Dr. Weninger uses stem cells to treat the meniscus tear.

His patients also receive a special scaffold to ensure that the stem cells reliably differentiate into fibroblasts, allowing the meniscus to heal. This method was published by Dr. Weninger and is one of his signature treatments, developed exclusively for his patients.

Nanoscopy with Stem Cells

As a knee specialist, PD Dr. Weninger uses an especially gentle surgical technique: nanoscopy. A nano-camera, no thicker than a needle, is used for the procedure. These interventions are combined with stem cells and are applied for the following conditions:

The procedure is performed under local anesthesia and is particularly gentle and effective.

Gold Implantation for Osteoarthritis

For advanced Grade IV osteoarthritis with severe pain, PD Dr. Weninger performs gold implantation. Tiny gold cylinders are implanted into the joint capsule under local anesthesia. This immediately down-regulates the inflammation triggered by osteoarthritis in the joint.

Patients are usually pain-free right away, and a prosthesis through major surgery can often be avoided. The procedure is particularly gentle and can be performed under local anesthesia.

Denervation for Grade IV Osteoarthritis

As a knee specialist, PD Dr. Weninger is an expert in pain elimination for Grade IV osteoarthritis. He uses needle-like electrodes to deactivate the pain fibers, providing patients with immediate relief. The procedure is particularly gentle and can be performed under local anesthesia.

Locations

Your Contact Points for Modern Treatment Methods

Here you can get an overview of our various locations where our innovative methods are successfully applied. Each location is staffed with experienced professionals and provides you with expert care. Find the location near you and experience our holistic approach firsthand.

Austria
Vienna

Am Hof 11/9, 1010

Austria
Vienna

Newaldgasse 2, 1090

From October 1, 2026

Heiligenstädter Straße 44
1190 Vienna

Contact

Get in Touch Now

Do you have questions or want to learn more about our services? Don’t hesitate to contact us. Whether by phone, email, or through our contact form – we are happy to advise you and personally take care of your request. We look forward to hearing from you!

ordination@dr-weninger.at

+43 699 17242838

Am Hof 11/9, 1010 Vienna